Scientists develop new ‘precision medicine’ approach to treating damaged DNA in pancreatic cancer

dna
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Scientists have developed a new “precision medicine” approach to treating the damaged DNA in the cancer cells of Pancreatic Cancer patients.

The findings mark an important step forward for potential treatment options for pancreatic cancer, improving the options and outcomes for a disease where survival rates have remained stubbornly low.

The study detailing the approach—led by the University of Glasgow and published in Gastroenterology—used cell lines and organoids that were generated from patients with pancreatic cancer to develop new molecular markers that can predict who will respond to drugs targeting DNA damage.

The researchers tested these markers using multiple drugs, and have developed a strategy that are now being taken forward into clinical trial. The trial will help doctors and researchers predict which patient will respond to which one of these drugs, either alone or in combination.

Funding for the trail has come from AstraZeneca and will now be included in the PRIMUS-004 clinical trial as part of the Precision-Panc therapeutic development platform for pancreatic cancer.

PRIMUS-004 is a ground-breaking pancreatic cancer trial, which aims to match patients with more targeted and effective treatment for their tumors. Run by Precision-Panc, a flagship therapeutic development program dedicated to pancreatic cancer—led by the University of Glasgow with major funding from Cancer Research UK—the trial brings a precision medicine approach to pancreatic cancer treatment for the first time in the UK.

The trial will open for recruitment in Glasgow shortly, with 20 other centers throughout the UK to follow.

Although survival for many types of cancer has improved, pancreatic cancer survival has lagged significantly behind in the last 40 years. The disease is particularly hard to treat, partly because it’s often diagnosed at a late stage.

A major limitation to treating pancreatic cancer effectively is that there are very few treatment options for patients with the disease. Currently, some patients with pancreatic cancer cannot repair damaged DNA in the cancer cells, which makes the cancer vulnerable to some new and established drug treatments.

Dr. David Chang, from the University of Glasgow’s Institute of Cancer Sciences, said: “Our study is a huge breakthrough in terms of what might be possible with future treatments. As part of our research, the strategy we’ve developed is extremely promising, and we’re very pleased and proud to see it now be taken into clinical trial. For us, this is a demonstration of a bench-to-bedside precision oncology approach to tackle this terrible disease.”

Michelle Mitchell, Cancer Research UK’s chief executive, said: “We urgently need new ways to treat pancreatic cancer. The disease only has a few treatment options and is generally diagnosed at a late stage, so survival has remained stubbornly low. The Precision Panc study offers a dynamic way to explore new tailored treatments, and it’s fantastic that we now have new drug candidates to add to the PRIMUS-004 trial. We look forward to seeing if these drugs, which have shown promise in the lab, have the same impact for people with pancreatic cancer.”

All the president’s medicine: How doctors are treating Donald Trump

The leader of the free world is now fighting his own battle with a virus that’s laid global siege — and a concoction of some experimental treatments is helping him do it.

Uncertainty and fear for the president’s well-being plunged a nation already in chaos into further crisis, amid a pandemic that has already killed more than 209,000 Americans.

Over the weekend, Trump’s personal physician, Dr. Sean Conley, said the president is “receiving all the standard of care and beyond,” doctors are “attacking the virus with a multi-pronged approach” and he has “continued to improve.”

PHOTO: A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.

A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.

A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.

Some experts have raised questions about the uniquely robust drug regimen now being administered to the president. Dr. Lew Kaplan, president of the Society of Critical Care Medicine and a surgeon at the University of Pennsylvania, saying that these types of “non-standard processes” can ” invite error.” This exact combination of medications has not been tested together yet in large-scale studies.

NIH treatment panel guidelines member Dr. Mitchell Levy insisted that there is no “miracle” drug yet available.

“If you look at our guidelines, we just don’t think there’s enough evidence to recommend one way or the other,” Levy, chief of pulmonary critical care at Warren Alpert Medical School of Brown University, told ABC News. “So little is proven. It’s like the Wild West, and he’s the president of the United States, and so you feel like, I want to do anything I can to prevent the disease from progressing. That often drives us to do things outside of the normal standard, and that is never a good idea. There’s a standard of care for a reason. With COVID-19, part of the problem is we’re never really sure what the standard of care is.”

Other experts are more optimistic

“All of these treatments shift the odds in your favor,” Dr. William Schaffner, professor of preventive medicine and infectious diseases at Vanderbilt University Medical Center, told ABC News. “None of them is a magic wand that suddenly makes you feel better,” he said, explaining

How doctors are treating Donald Trump

The leader of the free world is now fighting his own battle with a virus that’s laid global siege — and a concoction of some experimental treatments is helping him do it.

Roughly 42 hours after President Donald Trump revealed he and the first lady had tested positive for COVID-19, he tweeted out a video from Walter Reed National Military Medical Center assuring the public he was feeling “much better” since being given a sundry mix of medication which he called “miracles coming down from God.”

Uncertainty and fear for the president’s well-being plunged a nation already in chaos into further crisis, amid a pandemic that has already killed more than 209,000 Americans.

Over the weekend, Trump’s personal physician, Dr. Sean Conley, said the president is “receiving all the standard of care and beyond,” doctors are “attacking the virus with a multi-pronged approach” and he has “continued to improve.”

PHOTO: A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020. (Alex Edelman/AFP via Getty Images)
PHOTO: A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020. (Alex Edelman/AFP via Getty Images)

Of the combination of medicines and supplements now deployed to help him recoup, much of it is not yet definitively known to beat the novel coronavirus, but is thought to help mediate the virus’ symptoms and severity. There is as of now no drug “approved” by the FDA for COVID-19 treatment, though some have been given emergency authorization.

MORE: President ‘bored’ at hospital, not ‘out of the woods’

Some experts have raised questions about the uniquely robust drug regimen now being administered to the president. Dr. Lew Kaplan, president of the Society of Critical Care Medicine and a surgeon at the University of Pennsylvania, saying that these types of “non-standard processes” can ” invite error.”

NIH treatment panel guidelines member Dr. Mitchell Levy insisted that there is no “miracle” drug yet available.

“If you look at our guidelines, we just don’t think there’s enough evidence to recommend one way or the other,” Levy, chief of pulmonary critical care at Warren Alpert Medical School of Brown University, told ABC News. “So little is proven. It’s like the Wild West, and he’s the president of the United States, and so you feel like, I want to do anything I can to prevent the disease from progressing. That often drives us to do things outside of the normal standard, and that is never a good idea. There’s a standard of care for a reason. With COVID-19, part of the problem is we’re never really sure what the standard of care is.”

Other experts are more optimistic

“All of these treatments shift the odds in your favor,” Dr. William Schaffner, professor of preventive medicine and infectious diseases at Vanderbilt University Medical Center, told ABC News. “None of them is a magic wand that suddenly makes you feel better,” he said, explaining that Trump’s treatment plan was made respecting the parameters of available science.

The president’s doctors have said he is taking at

How doctors are treating Trump

The leader of the free world is now fighting his own battle with a virus that’s laid global siege — and a concoction of some experimental treatments is helping him do it.



a person driving a car: A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.


© Alex Edelman/AFP via Getty Images
A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.

Roughly 42 hours after President Donald Trump revealed he and the first lady had tested positive for COVID-19, he tweeted out a video from Walter Reed National Military Medical Center assuring the public he was feeling “much better” since being given a sundry mix of medication which he called “miracles coming down from God.”

Uncertainty and fear for the president’s well-being plunged a nation already in chaos into further crisis, amid a pandemic that has already killed more than 209,000 Americans.

Over the weekend, Trump’s personal physician, Dr. Sean Conley, said the president is “receiving all the standard of care and beyond,” doctors are “attacking the virus with a multi-pronged approach” and he has “continued to improve.”



a person driving a car: A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.


© Alex Edelman/AFP via Getty Images
A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020.

Of the combination of medicines and supplements now deployed to help him recoup, much of it is not yet definitively known to beat the novel coronavirus, but is thought to help mediate the virus’ symptoms and severity. There is as of now no drug “approved” by the FDA for COVID-19 treatment, though some have been given emergency authorization.


MORE: President ‘bored’ at hospital, not ‘out of the woods’

Some experts have raised questions about the uniquely robust drug regimen now being administered to the president. Dr. Lew Kaplan, president of the Society of Critical Care Medicine and a surgeon at the University of Pennsylvania, saying that these types of “non-standard processes” can ” invite error.”

NIH treatment panel guidelines member Dr. Mitchell Levy insisted that there is no “miracle” drug yet available.

“If you look at our guidelines, we just don’t think there’s enough evidence to recommend one way or the other,” Levy, chief of pulmonary critical care at Warren Alpert Medical School of Brown University, told ABC News. “So little is proven. It’s like the Wild West, and he’s the president of the United States, and so you feel like, I want to do anything I can to prevent the disease from progressing. That often drives us to do things outside of the normal standard, and that is never a good idea. There’s a standard of care for a reason. With COVID-19, part of the problem is we’re never really sure what the standard of care is.”

Other experts are more optimistic

Gallery: I’m a Doctor and Here’s What’s Trump Does Next (ETNT Health)

“All of these treatments shift the odds in your favor,” Dr. William Schaffner, professor of preventive medicine and infectious diseases at Vanderbilt University

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