Disc Medicine Expands Scientific Advisory Board with Leading Experts in Hepcidin Biology

CAMBRIDGE, Mass., Oct. 13, 2020 /PRNewswire/ — Disc Medicine, a company dedicated to the discovery and development of novel therapeutic candidates for serious and debilitating hematologic diseases, today announced the appointment of Tomas Ganz, MD, PhD and Elizabeta Nemeth, PhD to its scientific advisory board, adding valuable expertise in hepcidin biology.

Disc Medicine is a hematology company harnessing new insights in hepcidin biology to address ineffective red blood cell production (erythropoiesis) in hematologic diseases. Focused on the hepcidin pathway, the master regulator of iron metabolism, Disc is advancing first-in-class therapies to transform the treatment of hematologic diseases. (PRNewsfoto/Disc Medicine)

“We are thrilled to welcome  Dr. Ganz and Dr. Nemeth to our Scientific Advisory Board, particularly at such an exciting time in a field that they helped pioneer,” said John Quisel, JD, PhD, Chief Executive Officer at Disc Medicine. “Together they were instrumental in characterizing the fundamental role of hepcidin in iron homeostasis, and I’m delighted to be working with them as we advance our hepcidin-targeted programs into the clinic.”

Dr. Ganz is a Distinguished Professor of Medicine and Pathology at the David Geffen School of Medicine at UCLA, where he studies the role of small peptide regulators in human physiology and disease and is credited for the discovery of the iron-regulatory hormone hepcidin. Dr. Ganz received his PhD in Applied Physics from Caltech and his MD from UCLA, joining UCLA as a faculty member in 1983 after having completed training in Internal Medicine and Pulmonary Medicine. In 2005 he received the Marcel Simon Prize of the International Bioiron Society for the discovery of hepcidin and in 2014 was honored by the E. Donnall Thomas Award from the American Society of Hematology for his research in iron homeostasis, including the discovery of the iron-regulatory hormone hepcidin and investigation of its roles in iron metabolism.

“It has been immensely gratifying to see the hepcidin story unfold as our understanding of hepcidin’s role across different diseases has grown,” said Tomas Ganz, MD PhD. “Disc has taken a compelling approach to targeting hepcidin with two programs guided by human genetic findings. I’m delighted to be a part of this vision, particularly as they look to enter the clinic with their first program next year.”

Dr. Nemeth is a Professor of Medicine at the David Geffen School of Medicine at UCLA, and Director of the UCLA Center for Iron Disorders. Dr. Nemeth received her PhD in Cell, Molecular and Neurosciences at the University of Hawaii and completed a postdoctoral fellowship studying the pathobiology of hepcidin at UCLA. During her tenure she has made major contributions to the understanding of iron homeostasis and its dysregulation in disease, such as characterizing the regulation of hepcidin production by inflammation and iron and elucidating the mechanism of action of hepcidin in regulating dietary iron absorption and release from stores. Dr. Nemeth also described the role of hepcidin in various iron disorders including hereditary hemochromatosis, iron-loading anemias and iron-restricted anemias. Dr. Nemeth was a standing member of the Molecular and Cellular Hematology Study Section of the National Institutes of Health, is President-Elect of the International BioIron Society, and an associate editor of the American Journal of Hematology. Dr. Ganz and Nemeth co-founded three biotechnology companies focused on hepcidin-targeted

Lower Coast Algiers under boil water advisory after vehicle strikes fire hydrant |

Lower Coast Algiers residents were advised not to drink tap water Friday after vehicle struck a fire hydrant, reducing water pressure in the area.

A boil water notice remained in effect at 6:11 p.m., almost six hours after the New Orleans Sewerage & Water Board posted it. The agency said it might take 24 hours to obtain results of water quality tests.



A look at the New Orleans S&WB $39M plan that would repair and buy a new turbine, equipment

But City Council member demands improvements on customer billing

The S&WB issues boil water advisories in areas where pressure drops below 20 pounds per square inch. Pressure reductions in pipes could allow bacteriological contaminants to enter.

Healthy adults are cautioned that:

  • When washing hands, they may use soap and tap water, dry hands, then apply hand sanitizer. It’s safer to wash with bottled or boiled water.
  • When showering or bathing, they should be careful not to swallow any water. Infants, young children and disabled persons should be supervised to ensure water is not ingested. Residents with open wounds, chronic illness or weakened immune systems should use boiled or bottled water to bathe.

To boil water, bring it to a rolling boil in a clean container for a full minute. If the water has a flat taste afterward, shake it in a bottle or pour it from one container to another.

Source Article

EyeGuide Adds Six Sports Medicine, Neuroscience Experts to Scientific Advisory Board

The Daily Beast

Trump’s Jab on Hunter Biden’s Drug Addiction Horrifies Treatment Advocates

Even by the historically low standards of decorum and decency set by President Donald Trump’s pugilistic performance in his first presidential debate with former Vice President Joe Biden on Tuesday, the president’s attack on his opponent’s son for his past struggles with substance use was singular in its ugliness.“Are you talking about Hunter?” Trump said late into the debate, interrupting Biden as he reflected on his late son, Beau Biden, who died of brain cancer in 2015. “Hunter got thrown out of the military. He was thrown out, dishonorably discharged for cocaine use—he didn’t have a job until you became vice president, and once you became vice president, he made a fortune.”Trump’s callous and incorrect comments—Hunter Biden was not dishonorably discharged— about his opponent’s lone surviving son’s past drug use were clearly wielded to leave a mark, but Biden responded with defiance.“My son, like a lot of people, like a lot of people we know at home, had a drug problem,” Biden said. “He’s overtaken it. He’s fixed it, he’s worked on it, and I’m proud of him. I’m proud of my son.”The moment horrified advocates for addiction treatment and recovery who told The Daily Beast that they fear Trump’s comments, and comments like them, could make it harder for the millions of Americans affected by substance use to get help.“Addiction is a medical condition that affects millions of Americans each year, irrespective of any demographic. It is a disease, not a moral or character failing,” Marvin Ventrell, CEO of the National Association of Addiction Treatment Providers, told The Daily Beast. “It is inappropriate, harmful, hurtful, and irresponsible when a public figure or person of influence disparages people suffering from addiction.”“Pointing out a father because his son may have struggled in the past with a substance use disorder is wholly unconstructive and serves to perpetuate misconceived perceptions of addiction,” said Dr. Paul H. Earley, president of the American Society of Addiction Medicine (ASAM). “Our nation must respond with compassion and evidence-based treatments if we want to treat addiction and save lives.”Trump’s comments, which characterized substance use as a character failure, also undercut the hard-fought understanding in the medical community that addiction is a disease, said Dr. Lawrence Weinstein, chief medical director of American Addiction Centers, which provides treatment for substance use disorders.Trump Planned to Go Feral on Biden. Now His Allies Want to Call Animal Control“The stigma surrounding mental health and addiction has been shown to be a significant barrier to treatment and prevents many people from seeking the help that they need,” said Weinstein, who called addiction “an indiscriminate, chronic, complex and relapsing brain disease.”“This disease is not the result of a moral failing, poor judgment, or weakness—it is a chronic condition that requires lifelong maintenance,” Weinstein said.Trump has a track record of making flippant comments about substance use and addiction, despite the death of his elder brother to complications related to alcoholism. In recent years